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KMID : 0379520050210010023
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한국독성학회지
2005 Volume.21 No. 1 p.23 ~ p.29
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Reproductive Toxicity Study of CONP01, a New Antiarthritic Agent: Developmental Study in Rats
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Lee Jung-Suk
Hong Dong-Ho
Kim Kwang-Ho
Zhang Hu-Song
Gil Gi-Hyun
Han Myong-Kyu
Yang Hyun-Ju
Bae Jin-Sook
Kim Nam-Du
Song Si-Whan
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Abstract
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A developmental study of CONP01, a new antiarthritic agent, was conducted in Sprague-Dawley rats. Dosage of CONP01 0, 111, 333, and 1000 mg/kg/day were administered to dams orally from day 6 to day 16 of gestation. Two-third of dams per group were subjected to caesarean section on day day 20 of pregnancy for examination of their fetuses, and the remaining one-third of dams per group were allowed to deliver naturally for postnatal examination of their offspring. There was no change in the dams body weights, food consumptions, specific clinical sings and gross findings. There was significant decrease only in the absolute and relative weights of right ovary in 111 mg/kg treatment group, when compared with the vehicle control, whereas other organ weights were not changed. Moreover, no increase in the frequencies of external, visceral and skeletal malformation of fetuses were observed in the treated groups. These results suggest that the oral NOAEL (no observed adverse effect level) of CONP01 may be over 1,000 mg/kg in dams and fetuses of rats.
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KEYWORD
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CONP01, Antiarthritic agent, Developmental study, Rat
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